Exposures to some of the 4,000 or so members of the per- and polyfluoroalkyl substances (PFAS) class of chemicals have been associated with potential adverse health effects such as high cholesterol, low infant birth weight, reduced antibody response to vaccines and high blood pressure. While environmental studies of PFAS have advanced, gaps remain in our understanding of how much humans are exposed to PFAS from food and packaging, and the associated risks, if any.