Columbia, md. April 15, 2010 &ndash mettler toledo announced that donna blackmond of the scripps research institute and formerly of the imperial college of london will present the webinar reaction progress kinetic analysis a powerful methodology for streamlining the study of complex organic reactions on april 28, 2010. Mettler toledo is proud to offer this free webinar that discusses how the reaction progress kinetic analysis rpka methodology simplifies kinetic studies of organic reactions. Reaction progress kinetic analysis rpka streamlines kinetic studies by exploiting the extensive data available from accurate in situ monitoring of global reaction progress under &ldquosynthetically relevant&rdquo conditions, where the concentrations of two or more reactants are changing simultaneously &ndash in fact, in the same manner that they are expected to change during practical synthesis. This contrasts with the classical approach to kinetics, which uses concentration ratios that are highly distorted, typically ca. 10 equivalents, in order to examine the order in each substrate&rsquos concentration while holding the other constant. We have shown that the concentration dependences of two different substrates may be determined from far fewer reaction progress experiments compared to a classical kinetic approach. The reaction progress kinetic analysis rpka methodology is made straightforward for interpretation via the graphical manipulation of a mathematically determined minimum set of carefully designed experiments. One advantage of the rpka approach is that vital kinetic information may be rapidly obtained and extracted even in the earliest studies of a new reaction and may thus help inform the direction of both further reaction optimization and fundamental mechanistic investigation by other methods. The method requires little mathematical prowess and no specialized kinetic modeling techniques. The reaction progress kinetic analysis rpka methodology consists of two sets of experiments, called &ldquosame excess&rdquo and &ldquodifferent excess&rdquo experiments. The &ldquodifferent excess&rdquo protocol provides information similar to that obtained in classical kinetic studies, that is, it gives the order in various reactant concentrations. The principal advantage of rpka in this case is that this information is obtained from far fewer experiments than required for traditional kinetic analysis. However, it is in the &ldquosame excess&rdquo protocol that the rpka methodology is most innovative, because here it provides not simply the same information more rapidly and with higher accuracy, but it extracts information about a working catalytic cycle that is difficult to obtain by any other means &ldquosame excess&rdquo experiments help to differentiate a catalyst cycle that is operating at steadystate from one which is subject to temporal effects unrelated to the intrinsic reaction kinetics, such as catalyst activation or deactivation. The reaction progress kinetic analysis webinar guest presenter, donna g. Blackmond, received her ph.d. In chemical engineering from carnegiemellon university, and has enjoyed success in both the pharmaceutical industry and academia. In 2010, she joined the scripps research institute in la jolla, california as professor of chemistry. As a world renowned expert in reaction progress kinetic analysis rpka, professor blackmond&rsquos research focuses on blending the quantitative aspects of her chemical engineering background together with the synthesis of complex organic molecules by catalytic routes, particularly asymmetric catalysis with application in pharmaceutical processes. &ldquokinetics is the branch of chemistry which explains how fast chemical reactions go. Kinetics enables us to understand the driving forces of a reaction, to assess the robustness of catalytic processes, and to distinguish between proposed mechanistic models. This presentation will explain the fundamentals of reaction progress kinetics analysis rpka for catalytic organic reactions using in situ reaction progress measurement tools,&rdquo said nilesh shah, mettler toledo d2i project manager. Follow the provided link to register today for free webinar httpwww.mt.comglobalenhomeeventswebinarliveprogress.html about mettler toledo mettler toledo provides the enabling technology software and people that can help build a seamless workflow to translate bench scale chemistry into a commercial process. For more than 20 years, our enabling tools and services have been a strategic resource providing critical information for thousands of development scientists and engineers. Companies have used that knowledge to accelerate the discovery, development and scaleup of new chemical processes spanning the chemical and biopharmaceutical industries.
