Columbia Md April 15 2010 Ndash Mettler Toledo Announced That Donna Blackmond Of The Scripps Research Institute And Formerly Of The Imperial College Of London Will Present The Webinar Reaction Progress Kinetic Analysis A Powerful Methodology For Streamlining The Study Of Complex Organic Reactions On April 28 2010nbspmettler Toledo Is Proud To Offer This Free Webinar That Discusses How The Reaction Progress Kinetic Analysis Rpka Methodology Simplifies Kinetic Studies Of Organic Reactionsnbspreaction Progress Kinetic Analysis Rpka Streamlines Kinetic Studies By Exploiting The Extensive Data Available From Accurate In Situ Monitoring Of Global Reaction Progress Under Ldquosynthetically Relevantrdquo Conditions Where The Concentrations Of Two Or More Reactants Are Changing Simultaneously Ndash In Fact In The Same Manner That They Are Expected To Change During Practical Synthesis This Contrasts With The Classical Approach To Kinetics Which Uses Concentration Ratios That Are Highly Distorted Typically Ca 10 Equivalents In Order To Examine The Order In Each Substratersquos Concentration While Holding The Other Constant We Have Shown That The Concentration Dependences Of Two Different Substrates May Be Determined From Far Fewer Reaction Progress Experiments Compared To A Classical Kinetic Approach Nbspthe Reaction Progress Kinetic Analysis Rpka Methodology Is Made Straightforward For Interpretation Via The Graphical Manipulation Of A Mathematically Determined Minimum Set Of Carefully Designed Experiments One Advantage Of The Rpka Approach Is That Vital Kinetic Information May Be Rapidly Obtained And Extracted Even In The Earliest Studies Of A New Reaction And May Thus Help Inform The Direction Of Both Further Reaction Optimization And Fundamental Mechanistic Investigation By Other Methods The Method Requires Little Mathematical Prowess And No Specialized Kinetic Modeling Techniques The Reaction Progress Kinetic Analysis Rpka Methodology Consists Of Two Sets Of Experiments Called Ldquosame Excessrdquo And Ldquodifferent Excessrdquo Experimentsnbspthe Ldquodifferent Excessrdquo Protocol Provides Information Similar To That Obtained In Classical Kinetic Studies That Is It Gives The Order In Various Reactant Concentrations The Principal Advantage Of Rpka In This Case Is That This Information Is Obtained From Far Fewer Experiments Than Required For Traditional Kinetic Analysis However It Is In The Ldquosame Excessrdquo Protocolnbspthat The Rpka Methodology Is Most Innovative Because Here It Provides Not Simply The Same Information More Rapidly And With Higher Accuracy But It Extracts Information About A Working Catalytic Cycle That Is Difficult To Obtain By Any Other Meansnbsp Ldquosame Excessrdquo Experiments Help To Differentiate A Catalyst Cycle That Is Operating At Steadystate From One Which Is Subject To Temporal Effects Unrelated To The Intrinsic Reaction Kinetics Such As Catalyst Activation Or Deactivationnbspthe Reaction Progress Kinetic Analysis Webinar Guest Presenter Donna G Blackmond Received Her Phd In Chemical Engineering From Carnegiemellon University And Has Enjoyed Success In Both The Pharmaceutical Industry And Academianbspin 2010 She Joined The Scripps Research Institute In La Jolla California As Professor Of Chemistry Nbspas A World Renowned Expert In Reaction Progress Kinetic Analysis Rpka Professor Blackmondrsquos Research Focuses On Blending The Quantitative Aspects Of Her Chemical Engineering Background Together With The Synthesis Of Complex Organic Molecules By Catalytic Routes Particularly Asymmetric Catalysis With Application In Pharmaceutical Processesnbspldquokinetics Is The Branch Of Chemistry Which Explains How Fast Chemical Reactions Gonbspkinetics Enables Us To Understand The Driving Forces Of A Reaction To Assess The Robustness Of Catalytic Processes And To Distinguish Between Proposed Mechanistic Modelsnbspthis Presentation Will Explain The Fundamentals Of Reaction Progress Kinetics Analysis Rpka For Catalytic Organic Reactions Using In Situ Reaction Progress Measurement Toolsrdquo Said Nilesh Shah Mettler Toledo D2i Project Managernbspfollow The Provided Link To Register Today For Free Webinar Httpwwwmtcomglobalenhomeeventswebinarliveprogresshtml Nbspabout Mettler Toledonbspmettler Toledo Provides The Enabling Technology Software And People That Can Help Build A Seamless Workflow To Translate Bench Scale Chemistry Into A Commercial Processnbspfor More Than 20 Years Our Enabling Tools And Services Have Been A Strategic Resource Providing Critical Information For Thousands Of Development Scientists And Engineersnbspcompanies Have Used That Knowledge To Accelerate The Discovery Development And Scaleup Of New Chemical Processes Spanning The Chemical And Biopharmaceutical Industriesnbspnbspnbspnbspnbsp