What challenge is solved by nextaro®v?
During the manufacturing process (freeze drying) of lyophilisates, a negative pressure is created in the medication vial. During reconstitution, this negative pressure draws the solvent, e.g. WFI (water for injection), into the medication vial. However, there are also medications that require different process conditions during lyophilization, so that only a slight negative pressure is created in the active ingredient vial. This is where the mixing and transfer systems currently available on the market often reach their limits and the solvent is not completely transferred into the lyophilisate. The consequence is improper reconstitution, which can lead to a loss of quality or even render the valuable active ingredient solutions unusable . Another challenge in developing the product was the delicate construction of the plastic spike in the housing for piercing the plug. The few ventilated systems that are currently available often have solid plastic spikes, which often lead to scraping when piercing the stopper (coring) or sometimes push it completely into the vial.
How does the nextaro®v solve this challenge?
A specially developed and patented spike design on the water side of the transfer device enables ventilation during reconstitution. This results in a complete transfer of the solvent into the medication vial. When developing the particularly slim spike geometry, great attention was paid to stability, optimization of the puncture forces and the avoidance of punching effects from the vial stopper.
Your advantages when using nextaro®v:
- Reconstitution despite low negative pressure in the medication vial
- Up to two separate filters can be integrated
- The special spike geometry minimizes the stopper being pushed through into the vial
- Scrapes and punches from the plug are decimated
Avoid loss of quality and increase user safety with nextaro®v. Use the new quality standard for drug reconstitution. Discover how nextaro®v can improve your reconstitution processes and make them safer. Contact us for further information or a personal product presentation.
nextaro® - always one step ahead in terms of quality.
