Peptides Play A Critical Role In The Modern Physicians Toolkit But Peptides And Related Substances Present Unique Manufacturing Challenges Small Quantities Of Expensive Materials Are Typically Handmeasured Product Is Moved From A Singlesource Container To A Fixed Targetweight Batch In A Timeconsuming And Errorprone Method That Often Results In Costly Overfills Is There A Better Waymanually Sale Weights Ranging From 1 Mg To Several100 Mg Often Require 2 To 3 Minutesnbspper Fill To Achieve A Withintolerance Fill Substances Such As Peptides And Proteinsnbsprequire Multistep Synthesis Making Them Quite Expensivemdashand Not The Kind Of Thing Anynbspprocessor Or Distributor Relishes Giving Away For Freenbspoverfilling To Ensure Minimum Standards Are Met Can Reduce Already Thin Profit Marginsnbspbut Magnify The Giveaway Concern Repeat The Operation 30 100 Or 1000 Times In Onenbspbatch Manual Dosing Becomes A Fulfillment Quagmiremdashtiring For Operators Costly Fornbspcompaniesnbspautomated Cost Savingsone Swiss Biochemical Company Faced The Unenviable Logistical Challenge Of Supplyingnbspa Catalog Of More Than 4400 Chemicals On A Timely Basis To Pharmaceutical Industrynbspbuyers After Evaluating How Much Money They Were Losing To Overfills And To Meetnbspincreased Demand For Their Products The Company Began Seeking Ways To Enhancenbspproductivitynbspmettler Toledo Determined Quantos With An Autosampler Offered An Ideal Solutionnbspto This Manufacturerrsquos Bottling Challengenbspthe Quantos Doses 30 Target Vessels Of Differing Target Weights Without Operatornbspinteraction Taking 30to60 Seconds Per Vesselmdashfour Times Faster Than A Manual Fillnbspautogenerated Labels Simplified Filled Vial Tracking And Specialized Vialfitting Adaptersnbspreduce Electrostatic Effects Which Can Be A Concern With Automated Solutionsnbspthe Companyrsquos Productivity Increased More Than Fourfold In Just Ten Months Overfillingnbsphas Also Been Reduced From 9 To Just 2 Contributing To Significant Monetary Gainsnbspadded Benefits Of Exact Fillsautomated Exactness Is Critical Over And Underfills Risk Unintended Side Effects Andnbspunderfills Particularly Run Afoul Of Strict Biochemical Regulation Eu Regulation 76211ewg Alone States That Quotthe Actual Mass Of The Contents Of A Flask Can Vary To Maximumnbsp9 Compared To The Written Labelquotnbspwhen Considering These Production Pressures The Cost Of Implementing An Automatednbspsystem To Enhance Dosing Precision Pales In Comparison To The Potential Costs Of Notnbspdoing Somdashparticularly When Handling Small Amounts Of Expensive And Potentially Volatilenbspmaterials In The Highly Competitivemdashand Highly Regulatedmdashpharmaceutical Arenanbspfor More Specifics On Mettler Toledo Solutions For Automated Dispensing Ofnbspweights Between 1mg And 250mg To Improve Productivity And Reduce Costs Visitnbspwwwmtcomquantosnbspcase Study In Cost Savingsinstalling Two Combination Quantosautosampler Machines To Relieve Pressure Onnbspmanual Filling At One Manufacturer Resulted In The Following Savingsnbspnbspannual Consumable Costs 253000 Euronbspnet Investment Costs 4900000 Euronbsptotal Annual Gross Savings 6296885 Euronbspfiveyear Savings Will Equal 25249426nbspthe Automated System Paid For Itself In Less Than 10 Monthsnbspdosing Examplethe Table Below Shows A Summary Of Dosing Data From Multiple Replicates Of Four Typicalnbsppeptides At Varying Targetdose Amountsnbspsubstance Target Dosenbspmgmean Actualnbspdose Mgno Ofnbspreplicatesaccuracy Rsd Mean Dosagetime Snbspbocglnalaargamc 5 519 30 383 266 47sucalaalaalapna 1000 100509 31 051 028 228hdpheproarg 25 2539 75 158 104 23hippurylhisleuoh 250 25178 73 071 055 68nbsp3075 Samples Of Each Peptide Were Dosed On The Quantos Qb5 System In A Singlenbspbatch The Mean Dosing Time For Target Amounts Between 1 250mg Was 48 Secondsnbspaccuracy Of Dosing Is Typically Less Than 2nbspmettlertoledo Aglaboratory Divisionim Langacherch8606 Greifensee Switzerlandsubject To Technical Changescopy Mettlertoledo Ag 1109printed In Switzerlandquantos Marketing Switzerland