The innovative Syringe-Closure-Wrap marking solution features a label that wraps around the syringe barrel and the complete cap. When the user pulls off the upper part of the label, the integrated first-opening indication is triggered. Due to special security die cuts, the label is irreversibly destroyed and cannot be closed again unnoticed. After the label has been opened for the first time, an additional warning appears as a visible security element. For increased product and counterfeiting protection, overt, covert or digital authentication features can be integrated into the label.