roche employs a standard pack design for a number of clinical trials &ndash the contents make the difference the contained glass bottles are kept in place using an insert and the double walled design protects the bottles so well from all sides that the carton passed all the required tests. the insert is made of a single piece of cartonboard and bonded in one position only holders made of plastic or foam are no longer required. the approach was unusual instead of adapting the carton to the size of bottles and vials, a single carton size was developed for the various bottles. this resulted in an optimised form which replaced 90 per cent of the previous cartons for individual bottles a lean and safe portfolio with major advantages for both customers and manufacturers. labels, package inserts and storage capacities are now far easier to coordinate. the effect on sustainability has also been considerable less waste, reduced shipping costs and 100 recycling by using cartonboard as monomaterial.