To go into the human body, as a result, pharmaceutical stoppers must be no abnormal toxicity, no heat, nonhemolytic reactions, so as to make sure the safety and security of using medications. from rubber trees, natural rubber latex is collected after processed, and the main standard piece of rubber and rubber smoke is crafted. as a result of smoke of tobacco, technology of rubber chip contains 3 or 4 a stupid and pyrene cancer material. after processing is taking place, the concrete natural rubber, some plastic remains in the biological protein, the protein is dynamic allergic substance leading to harmful organisms, mould growth phenomenon. the results of accelerated mildew test indicate that the similar experimental situations, the natural rubber for the span of 7 days, there will be an extremely serious mildew situation and butyl rubber development for 21 days has no mold expansion. currently, china imported liquid bottle with natural rubber sega polyester film reason is to avert natural rubber stopper set of drug stain. natural rubber mainly thiazoles accelerator m, sulfur, dm, thiuram vulcanization accelerator tmtd as additives these chelating mediator has the prospective to skin allergies, reasoning cancer or organ malformation. while sulfide is a carcinogenic nitrosamines created hazards. after the procedure of vulcanization of natural rubber increased blood coagulation and biological reactivity. zinc oxide for natural rubber stopper of the "sanitation" influential, in particular for the bigger changes in ph amount of packaged liquor is more damaging to transfuse package by acid treatment considerably augmented the stopper of its white point that is the reason of this zinc oxide and sensitivity to few drugs and inaptness issues. it is possible to achieve butyl rubber without vulcanization accelerator, sulfur, zinc oxide cannot produce cork sulfurfree zinc. nowadays, in highquality bottles of cold, brominated butyl rubber is applied to polyamine as remedial agent has superior biosecurity. packaged drugs throughout the cork in the storeroom procedure of the penetration of water vapor and gases is extremely dangerous, it is the effect of drug degradation, an imperative reason. butyl rubber&rsquos permeability is natural rubber coefficient of 1 20, there are more outstanding than the natural rubber stiffness. along with this, cork rubber and a variety of ingredients in the manufacturing and processing process, inescapably some remaining impurities, such as resin, natural rubber hydrophilic protein, thus inevitably cause suction. as the structure of molecular of butyl rubber structure, characteristics, and their low water absorption, less hydrophilic impurities, usually natural rubber only 1 4 to 1 3. according to the previous soviet union initiated whilst the butyl rubber stoppers pharmaceutical covering, in relative humidity under 98 and 56c temperature, after the span of 72 days storage, the core properties of pharmaceutical drugs to preserve standards in the nation within the necessities of this assessment natural storage situation comparable to three years. cork should have low out of order and high purity to make sure the pureness of drugs. cork in the procedure of drug disclosure, and a rubber contamination will wander with the mediator to extract the cork out of the drugs or surface, destruction or pollution of drugs, decrease the efficacy. purity of butyl rubber as compared to natural rubber is around 10 times more, the natural rubber contained contamination is 1 8, and the blend of less formula, and thus removal of natural rubber is also a lot lower than that. stopper should be simple to use package, simple and convenient clinical appliance characteristics, butyl rubber stopper can be disconnected from natural rubber stopper in antibiotic at the time when the chloridepacking sealing wax procedure, eliminate the seal in the liquid when the polyester film encapsulation procedures, make simpler the repackaging procedure. butyl rubber stopper, which comes with a corresponding aluminium cover, for the plastic composite cover, is extremely convenient in clinical applications. the conventional natural rubber stopper enclosed with aluminium to aluminium cover xu yong aids scratched, extremely difficult to use, and simple to scratch stopper falling debris happened, resulting in pollution or damage, as well as the butyl rubber stopper of the plastic combined cap aluminium lid only a little open the cover of the plastic, rubber plug will be expose to make possible the injection of use. source of information httpnews.frbiz.comrubberstopperinthepharmaceutical307231.html
