Also, total sales of certain veterinary antimicrobial agents belonging to antibiotic classes that are considered critically important in human medicine noticeably decreased between 2011 and 2018. These classes include antibiotics used to treat serious infections in humans caused by bacteria resistant to most other antibiotic treatments. Sales of third- and fourth- generation cephalosporins dropped by 24%, polymyxins dropped by 70%, fluoroquinolones decreased by 4% and sales of other quinolones dropped by 74%.