There are many factors that contribute to low adherence, such as poor communication between doctors and patients and unwanted side effects. But according to ExpressScripts, 69% of nonadherence is behavioral, caused by forgetfulness or procrastination. Low adherence is a pain point for Pharma Clearly, these numbers are very concerning in terms of negative patient health outcomes, but what does this mean for the pharmaceutical industry? Pharma companies are losing hundreds of billions of dollars every year due to non-adherence.